ea0011p513 | Endocrine tumours and neoplasia | ECE2006
Mytakidis N
, Zachariou M
, Anagnostopoulos T
, Vassiliou E
, Thomas D
, Tertipi A
, Rampias T
, Konstantopoulou I
, Natsis P
, Yannoukakos D
, Kaldrymidis P
Familial medullary thyroid carcinoma (FMTC) is caused by germ-line mutations in the RET proto-oncogene. These mutations concern mainly exons 10 and 11, whereas mutations in exons 1316 are rare. Mutations in exon 8 have been reported in the literature only twice.We performed direct analysis of exons 719 and 21 of RET gene in two apparently unrelated Greek index-patients with FMTC, presenting negative initial screening for mutations in exons 10...